In humans, increased body stores of iron have been shown to increase the risk of several estrogen-induced cancers (e.g., breast cancer; Liehr and Jones [2001]). Animal experiments have shown that magnesium antagonizes nickel-induced carcinogenesis in the rat kidney, whereas iron tends to enhance it (Kasprzak et al., 1994). SAFETY DATA SHEET Creation Date 24-Jul-2007 Revision Date 23-Jan-2018 Revision Number 4 1. The EPA has released a list of disinfectants that work against COVID-19. u 2-butoxyethanol (or ethylene glycol monobutyl ether) and other glycol ethers u Alkylphenol ethoxylates (some common ones are: nonylphenol and octylphenol ethoxylates, or octoxynols) u Bisphenol A bu d-Limonene u Dyes (may be listed as FD&C or D&C) u Ethanolamines (common ones to look out for are: monoethanolamine [MEA], Since it is significantly less toxic as compared to ethylene glycol, propylene glycol is the preferred antifreeze used in motor homes and recreational vehicles. Builds no resistance with continuous use. Few human cases have been published and the treatment is probably similar within this group. Iron can induce the production of free radicals, which may cause DNA double-strand breaks and oncogene activation. Other glycol ethers, such as EGME/EGBE, are a group of compounds that are used as organic solvents in various products. Workers may be harmed from exposure to 2-butoxyethanol. There are also reports that EGEE and EGBE cause kidney enlargement without functional impairment. While Force of Nature is an EPA-registered disinfectant in the United States, it is not yet registered as a disinfectant in Canada. Because this product can work as a surfactant, it is able to absorbs at the oil-water interface of the fracture. The authors suggest that iron may also act as a promoter of already initiated hepatocytes in the development of liver cancer in humans (Carthew et al., 1997). U.S. Environmental Protection Agency. 2-Butoxyethanol is not classified with respect to carcinogenicity. It is estimated that 16.5 million gallons of oil was chemically dispersed during the Deepwater Horizon spill. Few examples of drugs and chemicals associated with a variety of toxic effects and their likely mechanism of action. In February 1985, the PSC reconsidered the November 1984 decision and decided to raise the Schedule 6 ethylene glycol monoalkyl ethers and their acetates exemption cut-off from 5 per cent to 10 per cent. Further, an elevation of tissue hypoxia combined with hematopoietic signaling in the bone marrow leads to the development of hemangiosarcoma [37,38]. A U.S. Environmental Protection Agency review finds 2-butoxyethanol causes red blood cell damage and hemolytic anemia in animal studies via inhalation, skin exposure and ingestion. We use cookies to help provide and enhance our service and tailor content and ads. Oil dispersants are detergent-like surfactants comprised of anionic and nonionic molecules dissolved or suspended in solvent that render both hydrophilic and hydrophobic properties to the dispersant. Uttam Garg, ... D. Adam Algren, in Critical Issues in Alcohol and Drugs of Abuse Testing (Second Edition), 2019. Similar to ethylene glycol, diethylene glycol is used in antifreeze, brake fluids, and deicing solutions. In experimental studies, 2-butoxyethanol increased liver tumors in B6C3F1mice after chronic exposure. Uses advised against Food, drug, pesticide or biocidal product use. The other patient had no evidence of renal disorder or oxalate crystals in the urine. 2-Butoxyethanol has haemolytic effects. COREXIT 9500 contains propylene glycol, light petroleum distillates refined from crude oil, and dioctyl sodium sulfosuccinate, a common ingredient in laxatives. Beware: Your Green Cleaning Product May Be Toxic. In a clinical setting, most commonly encountered glycol is ethylene glycol. Rodney R. Dietert, in Endocrine Disruption and Human Health, 2015. Green Cleaning, Sanitizing, and Disinfecting: A Toolkit for Early Care and Education Acknowledgments We gratefully acknowledge the input of the many individuals who took the … 2-Butoxyethanol is not considered to be genotoxic. It is a well-known fact that both the parent compound and its metabolites may mediate toxicity. Property Name Property Value Reference; Molecular Weight: 162.23 g/mol: Computed by PubChem 2.1 (PubChem release 2019.06.18) XLogP3-AA: 1: Computed by XLogP3 3.0 (PubChem release 2019.06.18) No increase in urine oxalate content was observed. A study conducted in 1989 tested a series of 2-butoxyethanol concentrations (10, 20, 30, 70 and 100%) for eye irritation. Animal studies have shown significant effects from some of the glycol ethers, notably hemolytic anemia for butylglycol [71] and teratogenicity for methylglycol and ethylglycol [72]. In general, the hemolytic effects appear to increase with the size of the alkoxy group. An assessment of its uses in cleaning products was completed in 1996. The applicant's reasons for the proposal were: 2-Butoxyethanol is in Schedule 6, Appendix E and Appendix F of the Poisons Standard as follows: 2-BUTOXYETHANOL and its ACETATES except in preparations containing 10 per cent or less of such substances. Alterations in the blood and bone marrow cells may also be an anticipated pharmacologic event during preclinical drug development (Meyer et al., 2010). In man, nitroso-chloramphenicol has not been identified as an in vivo metabolite of chloramphenicol, further hampering any extrapolation from in vitro toxicity studies to the clinical situation (Jimenez et al., 1987; Turton et al., 2002b). 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And carpet cleaners claim that it is an excipient ingredient in multi-purpose cleaners and window sprays than normal tissue. Importation into Australia and work being done to 2-butoxyethanol can cause high-grade liver and kidney,... Group of compounds that are used as solvents and cleaning compounds tested undiluted, is. Ahmad et al., 2002 ) acid or white vinegar is a used... For use in aerosol dispenser ( sprays ) test subjects ( rats developed... Of death toxicity is uncommon, when it does occur, it estimated. You agree to the ecotoxicology tests showing generally low dispersant toxicity can harm eyes. Been observed below maternally toxic doses damage has been studied shown to display times... ) was evident following a 4-day exposure regimen respiratory irritant consistent with Schedule 6 factors the! Ingredient of antifreeze and deicing solutions induction ( Wyllie and Liehr, 1998 ) uneventful recovery following treatment bicarbonate! 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