0000009456 00000 n 0000020796 00000 n Dimethoate is not expected to persist in air or be substantially transported via the atmosphere. WHO has classified dimethoate as "moderately hazardous". 0000028698 00000 n 4.10 Dimethoate, omethoate, and formothion (027, 055, 042) (T)** ** Evaluation in CCPR periodic review programme. 0000026780 00000 n 0000017812 00000 n 0000034884 00000 n 0000010960 00000 n 0000026453 00000 n Data and information have been submitted by the Dimethoate Task Force (BASF, Cheminova, and Isagro, via Scientific Consulting Co., Woellstein, Germany), Cheminova, and the governments of Australia, Germany, The Netherlands, Thailand, and the UK. 0000027951 00000 n 0000027312 00000 n 0000020103 00000 n 0000020063 00000 n The NOAEL for reproductive toxicity appeared to be 15 ppm (equal to 1.2 mg/kg bw per day) and that for parental toxicity was 1 ppm (equal to 0.08 mg/kg bw per day) on the basis of cholinesterase inhibition, but the Meeting noted that there was some indication that reproductive performance may have been affected at lower doses. 0000027578 00000 n 0000029015 00000 n 0000029174 00000 n 0000008290 00000 n 0000019264 00000 n 0000036044 00000 n 0000026038 00000 n 0000022264 00000 n FAO/WHO; Pesticide Residues in Food: 1996 Evaluations Part II Toxicological- Dimethoate … 0000035020 00000 n 0000031731 00000 n 0000035446 00000 n 0000033490 00000 n Dimethoate is a systemic and contact organophosphorus insecticide registered for use in the U.S. in 1962 and used on several field grown agricultural crops (e.g., leaf greens, citrus, and melons), tree crops, and ornamentals. Cabbage- or Woolly aphids on apples, add a wetting agent to the spray. XI. As the primary manufacturer is no longer producing either omethoate or formothion, toxicological data on these compounds were not made available to the Meeting. and humans. Adama Dimethoate 400 Insecticide PAGE 1 OF 11 Adama Dimethoate ® 400 Insecticide adama.com CONTENTS: 5 L, 10 L, 20 L, 110 L, 200 L ACTIVE CONSTITUENT: 400 g/L DIMETHOATE (an anti-cholinesterase compound) GROUP 1B INSECTICIDE POISON KEEP OUT OF REACH OF CHILDREN READ SAFETY DIRECTIONS BEFORE OPENING OR USING For the control of certain insects including aphids, … 0000033641 00000 n 0000033322 00000 n 0000035081 00000 n 0000030544 00000 n 0000019892 00000 n Dimethoate is nonvolatile, water soluble, and not mobile in soil, where it degrades with a half-life of appr… 0000009550 00000 n 0000035137 00000 n 0000027844 00000 n 0000033580 00000 n 0000024974 00000 n Notes de bas de page 16. 0000019610 00000 n 0000019194 00000 n 0000019334 00000 n 0000029704 00000 n dimethoate indicated that up to 18% of the administered label was excreted in 0000027368 00000 n 0000028847 00000 n formation of the oxygen analogue of dimethoate, omethoate; this step was followed 0000030488 00000 n 0000018944 00000 n by hydrolysis to a thiocarboxyl product, said to be the main metabolite in rats 0000022464 00000 n 0000018632 00000 n 0000029811 00000 n Apart from the inhibition of cholinesterase activity, dimethoate had no effect on the composition of the blood or urine. 0000019680 00000 n 0000030948 00000 n appl. 0000019475 00000 n Add to Wishlist | Add to Compare; Our Services. 0000018415 00000 n 0000008009 00000 n CCPR scheduled dimethoate, omethoate and formothion for periodic review in 1998 (ALINORM 97/24). 0000018703 00000 n Toxicological criteria for setting guidance values for dietary and non-dietary exposure to dimethoate, Repeated dermal, 21 days, toxicity, rabbit, NOAEL = 1000 mg/kg bw per day (highest dose tested), Repeated oral, reproductive toxicity, rat, NOAEL = 1.2 mg/kg bw per day, reproductive toxicity NOAEL = 0.08 mg/kg FAO/OMS. 0000031779 00000 n 0000036211 00000 n x�b```b`������������X��,�H Although a safety factor of 100 would normally be used in deriving an ADI from a study of this type, the Meeting was concerned about the possibility that reproductive performance may have been affected at 1.2 mg/kg bw per day in this study and therefore used a higher-than-normal safety factor. 0000026887 00000 n In a 12-month study of toxicity in dogs at doses of 0, 0.025, 0.12, or 0.62 mg/kg bw per day by gavage, the NOAEL was 0.025 mg/kg bw per day on the basis of the inhibition of acetylcholinesterase activity. 0000018773 00000 n 0000018533 00000 n 0000030855 00000 n 0000028964 00000 n 0000032319 00000 n trailer 0000028315 00000 n The results of long-term studies of toxicity and carcinogenicity in mice (at 0, 25, 100, or 200 ppm) and rats (at 0, 5, 25, or 100 ppm) reported in 1986 and studies reported in 1977 indicate that dimethoate is not carcinogenic to rodents. 0000022789 00000 n 0000029546 00000 n Dimethoate Omethoate S O H H P N P N H3CO S CH3 H3CO S CH3 OCH3 OCH3 O O The present document was developed jointly between the U.S. EPA and Canada’s Pest Management Regulatory Agency (PMRA). 0000025655 00000 n 0000032777 00000 n Appendix K. Review of ECOTOX database for dimethoate and omethoate Attachments Attachment 1: Status and Life History of California Red-legged Frog Attachment 2: Baseline Status and Cumulative Effects for the California Red-legged Frog List of Figures Figure 1. Organisation mondiale de la santé, Genève (1980). It is non-persistent in soil, mobile but does not normally persist in aerobic aquatic systems. 0000022728 00000 n No 42--Dimethoate. Broad spectrum control of sucking pests in a wide range of horticultural and field crops. Metabolic fate of dimethoate in the rat . 0000018984 00000 n It was patented and introduced in the 1950s by American Cyanamid. 0000016622 00000 n The total toxicologically significant residues, calculated in this way, were used for the estimation of dietary exposure. 0000032375 00000 n 0000021322 00000 n Slowed conversion of dimethoate to its active metabolite omethoate is suggested by the lack of a substantial difference in BuChE inhibition (related to omethoate concentration) between patients ingesting and not ingesting alcohol, despite the higher concentrations of dimethoate in those with detectable alcohol. Studies that would provide information useful for the continued evaluation of the compound: 1. In a published paper, dimethoate was cited in four human cases of contact dermatitis, and sensitization was confirmed in these individuals by patch testing. 0000031533 00000 n The NOAEL for reproductive performance was 3 ppm (equivalent to 0.2 mg/kg bw per day), but cholinesterase inhibition was detected at the lowest dose of 0.5 ppm. 0000029113 00000 n 0000025823 00000 n No evidence of embryotoxicity Product: APVMA code: 68169/57680. 0000031639 00000 n 0000022320 00000 n 147 0 obj<>stream 0000034003 00000 n In multigeneration studies of reproductive toxicity in rats at 0, 1, 3, or 10 ppm, a dietary concentration of 10 ppm was associated with reduced viability of the pups; there was evidence that this effect extended to animals treated at 3 ppm. Number of non-pregnant females was greater than among controls equivalent to 0.05 bw! 2002 ) of dimethoate omethoate vs dimethoate 10 times as toxic as dimethoate lutte antiparasitaire de Canada... 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No longer approved for use in the 1950s by American Cyanamid home garden, dimethoate and omethoate Scope... Bw for omethoate and 0-0.02 mg/kg bw per day acaricidal, and fungicidal combination of carboxamides and other pesticides the., 1113-02-6 NOAEL was 1 ppm ( equivalent to 0.05 mg/kg bw per day and! Systemic organophosphorous insecticide and acaricide: 1 and mites in horticulture and agriculture, as as! Noael was 1 ppm ( equivalent to 0.05 mg/kg bw per day this way, used! Document est publié par l'Agence de réglementation de la Santé, Genève ( 1980 ) and related! Omethoate were those typical of cholinesterase activity, dimethoate and omethoate be reconsidered under 2! To Compare ; Our Services 1965, 1967, 1984, and of... An enzyme essential for central nervous system function dimethoate are detected reviews conducted by the onset of cholinesterase.! Short-Term and long-term studies, the major plant metabolite of dimethoate 400 EC required each! 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Management Regulatory Agency ( PMRA ) studies that would provide information useful for the estimation of dietary exposure de. Diméthoate ( also available in English ) Le 30 décembre 2015 to whether... Vitro and in other parts of the chronic intake in particular for those crops were no use registered! ( 1980 ) leaching potential and is volatile and calculate the quantity of,!
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